Morphea caused by stress. Being too busy to spend time with each other and share responsibilities. Morphea (mor-FEE-uh) is a rare condition that causes painless, discolored patches on your skin. The major causes of scleroderma include multitude of factors such as immune imbalance, oxidative stress, genetics and environment factors. Therefore, it would stand to reason that stress could trigger an autoimmune response. Affected patients present with single or multiple inflammatory and sclerotic plaques, findings considered manifestations of active disease. Localized scleroderma typically causes patches of thick, hard skin in one of two patterns. The patches usually fade after a few years, although the skin may be permanently darkened where they appeared. Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. 1%, 291/581) in the cohort. feelings of overwhelm. This, in turn, helps with the overall well-being of the person. Morphea is an autoimmune disease that causes sclerosis, or scarlike, changes to the skin. The first signs of systemic scleroderma are often cold sensitivity ( and puffy fingers. Skin sores or ulcers can occur due to lack of good blood flow in some cases. A moisturizer with camphor and menthol can help cool your skin and relieve itch. Keep your skin, particularly your fingers and toes, covered and warm. Or your doctor may suggest hydroxychloroquine (Plaquenil) or Jan 10, 2022 · Morphea has also been reported to occur in association with radiation therapy [1, 11]. Perform gentle stretches to keep skin and joints flexible. Information Center. The estimated incidence of the disease is 0. Joints: Stiffness, swelling and loss of mobility (how easily you can move your joint). Morphea is characterized by an area of inflammation and fibrosis (thickening and hardening) of the skin due to increased collagen deposition. The worry is out of proportion to the actual circumstance Jun 6, 2023 · Introduction. Sep 29, 2023 · Systemic sclerosis can also cause symptoms in other organs and tissue, like your: Muscles: Numbness and swelling, especially in your hands and feet (your extremities). The muscles eventually harden and break down while the joints Sep 7, 2022 · Hydroquinone. Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. Higher levels of psychological distress were significantly related to greater severity of skin disease; more Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. Morphoea is a rare skin condition where patches of skin become hardened and lose their normal texture, becoming shiny. Jul 1, 2018 · Abstract. Activity in morphea is characterized histologically by an inflammatory dermal and subcutaneous lymphocytic infiltrate manifesting clinically as erythema, edema, and lesion extension, with patients reporting symptoms such as pain and pruritis (). Jun 24, 2013 · Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tissues. It is thought to be isolated to the skin without internal organ involvement as seen in systemic sclerosis (commonly known as scleroderma). ; Raynaud’s phenomenon: Hands and feet have an abnormal response to cold temperatures or anxiety. It is characterized by inflammation, excessive collagen production, and subsequently limited sclerosis of the skin; however, in some cases, deeper tissues such as subcutaneous fat, fascia, muscles, or bones might also be involved. Dec 24, 2022 · Morphea. Apply soothing lotions such as raw coconut oil or shea butter. Morphea is also known as localized scleroderma, is a rare autoimmune condition that causes painless, discolored patches on your skin 1, 2, 3. Limited scleroderma is the most common type of scleroderma. Case number and author. However, in scleroderma the balance of Nov 17, 2017 · Morphea, also known as localized scleroderma, is characterized by fibrosis of skin and subcutaneous tissue. GARD Genetic and Rare Diseases. Morphea may occur within months of initiating radiation therapy, or as long as 20 years later . Anyone can get lichen sclerosus but postmenopausal women are at higher risk. The condition is rare and thought to affect less than 3 out May 18, 2021 · However, this concept is a cause of confusion because it is used interchangeably with the term scleroderma, which is mostly perceived as a systemic sclerosis. When someone confronts an oncoming car or other danger, the eyes or ears (or both) send the information to the amygdala, an area of the brain that contributes to emotional processing. Feb 26, 2018 · Morphea. Morphea is a rare autoimmune condition causing inflammation and sclerosis of the skin and underlying soft tissue. Furthermore, in certain types it may be associated with extracutaneous manifestations that may lead to functional impairments, cosmetic disfigurements, psychological stress as Aug 25, 2022 · Morphea is a rare skin condition characterized by small red or purple patches that develop firm white or ivory centers. Ulcer formation on the fingertips or toes. Jul 26, 2022 · The signs and symptoms of Morphea can include: Hardening and tightening of the skin in a patch or plaque formation, which can be ovals or straight lines. The alterations to the skin caused by morphea have different degrees of impact on a person's quality of life and can lead to irreversible physical and psychological damage (Arkachaisri 2010; Bielsa Marsol 2013; Kroft 2009b). There is no specific treatment for morphea caused by stress. 1-888-205-2311. Some of the stress management techniques you can Sep 3, 2016 · Localized scleroderma (LS) (morphea) is a chronic, inflammatory skin disease with unknown cause that progresses with sclerosis in the skin and/or subcutaneous tissues. Morphea is associated with cosmetic and functional sequelae, and internal organ Nov 27, 2021 · like emotional stress, which results in Raynaud attacks. 3%, 187/291) than other morphea subtypes. Subtypes of morphoea vary according to the May 14, 2020 · Keeping the lesions moisturized can help relieve itching. 1%, 11/99, P < . For severe or widespread morphea, your doctor may prescribe an immunosuppressive medication, such as oral methotrexate (Trexall), corticosteroid pills or both. Linear scleroderma. 001). GARD can help. We have aimed to determine the relationship of morphea lesions with oxidative stress. These data indicate that stress caused by the loss of homes led to a marked increase in medical problems among evacuees, especially mental illnesses, such as depression. Some of the stress management techniques you can Morphea (localized scleroderma) is an autoimmune disease of the skin and underlying connective tissue that impairs quality of life and physical function in adults and children. However, stress management techniques can help reduce stress. The increase in collagen production resulting from skin fibrosis can arise from endothelial cell injury, immunological factors (for example, relating to T lymphocytes) and inflammatory activation and dysregulation of collagen production. The affected skin becomes tight and less flexible. Morphoea (American spelling, morphea) is characterised by an area of inflammation and fibrosis (thickening and hardening) of the skin due to increased collagen deposition. It is also known as localised scleroderma. What is morphea? Jul 8, 2019 · Circumscribed superficial (plaque morphea) and generalized morphea are common in adult-onset morphea , while linear scleroderma, both linear trunk/extremity and linear head subtypes, is more common in childhood-onset morphea (10, 11). Lungs: Coughing and shortness of breath ( dyspnea ). It is characterized by periods of activity (inflammation admixed with fibrosis), ultimately resulting in permanent damage (pigment change and tissue loss). Apr 1, 2020 · Introduction. Edges: Red or bruised looking. Morphea lesions have 5 main presentations: (1) circumscribed (few circles on the trunk or limbs); (2 Oct 10, 2020 · Chemical-induced sclerodermoid disease (CISD) is a scleroderma-like disorder that most commonly affects those working industrial jobs with chemical exposure. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Two of the symptoms listed above are often early signs of scleroderma. Drink plenty of filtered water. 1,2 Cutaneous signs of CISD include acrosclerosis and morpheaform plaques. Linear morphea participants with deep involvement were more likely to have a limitation in range of motion (28. Morphea is defined by periods of activity (inflammation and fibrosis) which leads to damage and atrophy. These areas may have a yellow, waxy appearance surrounded by a reddish or bruise-like edge. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. a disease in which only the skin and adjacent structures are involved in locations different than those observed in systemic sclerosis. The symptoms of morphea differ depending on the stage and severity of the condition. Herein we report two cases of generalized morphea probably induced by the COVID-19 vaccine, given the temporal relationship with its administration. Damage resulting from unchecked activity can lead to devastating Morphea. Blood vessels narrow when you are cold or stressed, turning fingers and toes white or blue before blood flow is restored and they return to a normal color. depression. It is also found in the gastrointestinal tract, blood vessels, and other organs. Jul 6, 2022 · loss of your sense of humor. [ 1 May 14, 2020 · It ranges from solitary sclerotic lesions, which usually cause a few problems to severe complications caused by the linear subtype that may result in limb length discrepancies and joint contractures . Morphea or localized scleroderma is an inflammatory immune-mediated disease that is associated with increased collagen deposition in the dermis and/or subcutaneous tissue leading to skin fibrosis. We sought to examine the molecular landscape of morphea by examining lesional skin gene expression and blood biomarkers and comparing the gene expression profiles with those from site-matched nonlesional and SSc lesional skin. Its extracutaneous manifestations are musculoskeletal, neurologic, and ophthalmologic. The rash may be itchy but not painful. Since the cause of the disease has not yet been clarified, localized scleroderma can only be treated symptomatically. A type of localized scleroderma, morphea causes thickened, oval patches on the skin with a white center and reddish or purplish border. e. Linear morphea was the most common morphea subtype (50. It causes patches of tight, hard skin that can vary in size, shape, color, and location. (c–d) Figures show the presence of Nov 28, 2023 · Common relationship stressors include: . 2. Stress is a natural human response that prompts us to address challenges and threats in our lives. Stress causes alterations in the production of cytokines and other immune cells. 1 The COVID Nov 1, 2021 · Lichen planus (LP) is a T cell-mediated disease affecting the stratified squamous epithelia of the skin and/or mucus membrane. LP has three major subtypes: Cutaneous, mucosal and appendageal LP. 1. Furthermore, in certain types it may be associated with extracutaneous manifestations that may lead to functional impairments, cosmetic disfigurements, psychological stress as Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. 4-2. Jan 18, 2023 · Although morphea is rarely life-threatening, the disease is characterized by a chronic, relapsing–remitting course, which can cause a lot of disease burden over time. Yoga is a great option. To achieve personalized management schemes, these factors shall be taken into account. You may blame sickness for that annoying headache, your sleeping troubles, feeling unwell or your lack of focus at work. Triple combination cream (tretinoin, corticosteroid, and hydroquinone) Azelaic acid, kojic acid, or vitamin C. CISD has been well-reported, secondary to aromatic hydrocarbon, vinyl chloride, epoxy resin, and pesticide exposure. 1-3 Disease activity in patients with morphea is characterized by periods of inflammation with new or expanding lesions, followed by sclerosis, permanent atrophy Aug 25, 2022 · For severe or widespread morphea, treatment may include the use of ultraviolet light (phototherapy). Stress can lead to changes in your immune system. This can cause restricted movement of the affected area of the skin. 1,2,3 Patients with extensive involvement unresponsive to phototherapy, with facial involvement, or with involvement traversing joints require systemic treatment to prevent disease progression and its associated morbidity. Design: Cross-sectional study. The thickened skin in scleroderma is caused by overproduction of collagen, which is the basic component of scar tissue. Jul 7, 2017 · Morphea is a skin condition that involves a patch or patches of discolored or hardened skin on the face, neck, hands, torso, or feet. It is the opinion of the authors that the term localized scleroderma should be avoided. Another form of localized scleroderma is linear scleroderma. Everyone experiences stress to some degree. The pathogenesis of scleroderma involves immune imbalance and generation of auto antibodies. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody Morphea, also known as localized scleroderma, is a condition which causes hardening and discoloration of the skin. Morphea, also known as localized scleroderma (LoS), encompasses a spectrum of autoimmune cutaneous connective tissue diseases. Irregular pigmentation of skin. This form usually starts when someone is a child or teenager. Some of the stress management techniques you can Results: Psychological functioning was generally impaired in patients with skin disease, particularly among patients with generalized morphea and eosinophilic fasciitis. 7 per 100,000 people, equally affecting children and adults, with a female predominance. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue involvement. loss of interest in life or activities. Twenty-eight patients (38%) were at risk of depression or anxiety. Excess collagen can also damage blood vessels. 4 and 27 cases per 1,00,000, and it is more common with a ratio of 2-4:1 in females to males [1,3]. Its pathogenesis is not completely understood. The morphea rash patches can grow together and form larger rashes. When occurring in the Oxidative stress causes DNA fragmentation, telomere erosion, and alters the nucleic acid translation and transcription processes (Guachalla and Rudolph 2010). Although the cause of morphea remains poorly investigated, genetic predisposition, immune dysregulation, and environmental factors have been implicated. Morphea, also known as localized scleroderma, is an autoimmune skin disorder characterized by inflammation and sclerosis of the skin and soft tissues. Jul 30, 2021 · 1. (a–b) Figures show the presence of multiple cutaneous lesions involving more anatomic areas in the same patient (Case patient 1). Circumscribed scleroderma or morphea is an inflammation-related skin disease that can probably be traced back to a malfunctioning immune system and which usually affects more women than men. The fingers may become: Highly sensitive to the cold and change color with cold or emotional stress (the symptoms of Raynaud’s phenomenon) Stiff and puffy. You and your partner are not communicating. It isn't contagious and can't be spread through sexual contact. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias Scleroderma is an autoimmune disease in which the body produces too much collagen, a fibrous protein that is a major component of the body’s connective tissues, including the skin, muscles, bones, tendons, and cartilage. Morphea is an inflammatory, sclerosing skin disorder that can involve the underlying soft tissues. It is not hereditary but seems to be more common in people with autoimmune conditions and these can run in families. The treatment approach for morphea caused by stress is almost the same as for morphea caused by other issues. When it perceives danger, it instantly sends a distress Oct 20, 2021 · Pansclerotic morphea is a type of severe and progressive generalized morphea that deeply spreads into the subcutaneous tissue and invades the muscles, tendons, and bones. Adult Dec 18, 2023 · Color: Red, purple, or yellow and waxy. Stress symptoms may be affecting your health, even though you might not know it. Raynaud's phenomenon, skin discoloration due to the abnormal spasm of the blood vessels causing a diminished blood supply to the Morphoea. Morphea, like scleroderma, is characterized as a sclerosing skin disorder, due to characteristic histological findings shared by both disorders, including sclerosis of the dermis and sometimes subcutis in the absence of fibroblast proliferation. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Abnormal accumulation of collagen is called fibrosis. The accumulation of DNA damage could result in cell-cycle arrest and apoptosis through the production of tumor suppressor proteins such as p16 INK4 , and p27 Kip1 (Zannoni et al. Several clinical assessment methods have been developed to monitor morphea, such as depigmentation, induration, erythema, and the telangiectasia (DIET) score, the modified Rodnan skin score (mRSS), and the Localized Scleroderma Assessment Tool (LoSCAT) (12, 17). Linear morphea involves lesions in a line resembling a scar. It Jan 10, 2022 · That pressure alone is extraordinarily stressful. The way we respond to stress, however, makes a big difference to our overall well-being. Some of the stress management techniques you can Morphea is extremely varied clinically, with heterogenous subtypes. existing mental health conditions get worse. Participants: Of 120 patients with morphea or eosino-philic fasciitis diagnosed between December 1, 1994, and July 15, 2007, who were enrolled in the study, only 74 completed questionnaires were suitable for data Nov 8, 2016 · Morphea, also called localized scleroderma, is a chronic autoimmune disease characterized by inflammation and sclerosis of the skin. Finding the right health care provider or getting the correct diagnosis may prove challenging. A recent review summarized 66 cases of morphea, which represented approximately 0. Setting: Dermatology outpatient clinic of a university hospital. Jun 3, 2019 · In cases where hands or legs are involved and limit movement, stretches can help. Oxidative stress is suggested to have a role in the pathogenesis of localized scleroderma. 6%, 55/192) than those without (11. These plaques eventually become inactive, leaving permanent dermal or soft There is no specific treatment for morphea caused by stress. Contact a GARD Information Specialist if you need help finding more information on this rare disease or available clinical studies. Generalized anxiety disorder includes persistent and excessive anxiety and worry about activities or events — even ordinary, routine issues. May 4, 2018 · Anxiety disorder due to a medical condition includes symptoms of intense anxiety or panic that are directly caused by a physical health problem. This can cause numbness, pain and a white or bluish appearance to the fingers (Raynaud’s phenomenon). In addition, try a warm (not hot) bath with baby oil or oatmeal to soothe your skin. When melasma is stubborn, or you want to promote faster results, your healthcare provider may advise using one of the following procedures: Chemical peel. 2006 ). Localized scleroderma is a rare disease of unknown etiology. All the reported cases in the literature of patients developing morphea following COVID‐19 vaccine including this case report. Autoimmune disease occurs when the body’s natural defence system cannot tell the difference between your own cells and foreign cells, causing your Morphea is a form of scleroderma that mainly involves isolated patches of hardened skin on the face, hands, and feet, or anywhere else on the body, usually with no internal organ involvement. Scleroderma causes hardening of the skin, as well as hardening of the body’s connective tissues, and can damage internal organs. To ease the discomfort of scleroderma: Get sufficient rest. Morphea has an incidence rate between 3. Furthermore, according to the Reconstruction Agency data, over 1,700 residents of Fukushima died from complications related to stress and other problems following the accident. There is abuse or control in the relationship. May 31, 2023 · The disorder causes severe skin lesions and poor wound healing, leading to deep scarring of all layers of the skin and muscles. Stress affects every organ when our body is under duress. Jan 23, 2018 · Symptoms. Structural deformities and cosmetic disabilities caused by some types of the disease might greatly affect the quality of life. Localized scleroderma, also known as morphea, is a rare autoimmune disease that affects only the skin and the structures directly under the skin. Unlike systemic sclerosis, localized scleroderma does not usually spread to other parts of the body or cause Apr 3, 2024 · The stress response begins in the brain (see illustration). Therefore, patients with morphea might present different impacts of the disease on QoL in different stages of the disease. The term 'scleroderma' covers various types of morphoea and systemic sclerosis . Limited scleroderma affects the skin on the face, fingers, hands, and lower arms and legs. Deep involvement was more common in linear (64. Physical symptoms of stress may include the morphea or eosinophilic fasciitis. These patches can show up in a few places or all over the body. Apr 1, 2018 · This causes confusion with systemic sclerosis (scleroderma), often resulting in unnecessary evaluation and anxiety. Abstract. Oral medications. Autoimmune diseases occur when the immune system, which normally protects us from bacteria, viruses, and fungi, mistakenly attacks a person’s own body. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Localized scleroderma is synonymous with morphea, i. It’s the most common type in adults. Some common signs and symptoms include: patches of reddish or lilac skin, most commonly on the torso May 15, 2020 · There are several types of morphea, depending on the spread and deepness of the lesions: Circumscribed morphea is morphea localized in 1 to 3 areas. Feb 13, 2023 · Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue disorder with variable clinical presentations, that affects both adults and children. Feb 16, 2023 · Lichen sclerosus (LS) is a chronic mucocutaneous immune-mediated disease which typically involves genital skin. Jul 9, 2019 · In general, morphea is monitored clinically through the visualization and scoring of skin changes over time (Figure 1). Morphea (localized scleroderma) is a rare sclerosing disorder of the skin and subcutaneous tissue that affects patients of all ages. Generalized morphea affects four or more patches and may also cause fatigue and joint pain. Apr 17, 2018 · Scleroderma (systemic sclerosis, SSc) is an autoimmune disease characterized by vascular abnormalities that include Raynaud's phenomenon (RP), pulmonary arterial hypertension, fibrosis of skin and visceral organs. Jun 17, 2022 · Stress can be defined as a state of worry or mental tension caused by a difficult situation. We do not know what causes morphoea, but it seems to affect slightly more females than males. These symptoms happen because the blood vessels narrow due to spasm. 2% of breast cancer patients undergoing radiation therapy . Apr 5, 2023 · Morphea is an inflammatory fibrotic disorder of the skin that has been likened to systemic sclerosis (SSc). There are different subtypes of morphea, with different characteristics: circumscribed morphea is generally less severe than the other subtypes; linear scleroderma can cause significant body differences, possibly affecting growth in children; generalised morphea is a severe type involving multiple areas of the body; pansclerotic morphea is a I was diagnosed with morphea when I was 14, which has contributed to a lot of body confidence issues. Introduction. Because morphea may result in a physical deformity Lichen sclerosus (LIE-kun skluh-ROW-sus) is a condition that causes patchy, discolored, thin skin. It is characterized by inflammation and fibrosis of the skin and underlying soft tissue, in certain cases even of the surrounding structures such as fascia, muscle, bone Apr 30, 2021 · Morphea is an autoimmune disorder characterized by inflammation and sclerosis of the skin and underlying soft tissues. Morphea in children may cause growth retardation and muscular atrophy of affected limbs as well as limitation of range of motion and contracture, especially in deep lesions spanning joints or affecting the majority of the surface area of an extremity. Intimacy and sex are become rare due to busyness, health problems, and any number of other reasons. The term was first coined by Hallopeau in 1887 and it received multiple names such as kraurosis vulvae, balanitis xerotica obliterans, white spot disease, leukoplakia and lichen sclerosus et atrophicus. Choose a thick cream rather than a lotion, and apply it twice a day for best results. Available toll-free Monday through Friday from 12 pm to 6 pm Eastern Time. May 6, 2017 · Morphea affects only the skin; it doesn’t involve other organs. Mar 5, 2024 · Morphea, also known as localized scleroderma, is an idiopathic inflammatory disorder that causes sclerotic changes in the skin. The Mar 13, 2019 · Morphea causes functional, psychologic, and neurologic complications. Feb 13, 2023 · Although morphea is rarely life-threatening, the disease is characterized by a chronic, relapsing–remitting course, which can cause a lot of disease burden over time. The patches may stay in one area or spread to other areas of skin. . Contact a GARD Information Specialist to receive the individualized support you may need. Sep 1, 2020 · Morphea activity versus damage. In scleroderma, researchers believe the What causes morphoea? The cause of morphoea is unknown, but it is not contagious. Feb 1, 2011 · Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Raynaud’s phenomenon causes the skin of the fingers to look white or blue with cold temperature exposure or emotional stress. [1] However, in Deep Morphea inflammation and sclerosis can be found in the deep dermis, panniculus, fascia, superficial muscle and bone. Jun 1, 2019 · Scleroderma is an autoimmune disorder, characterized by morphological changes in skin followed by visceral organs. It usually affects the genital and anal areas. Aug 25, 2022 · Departments and specialties. Histologically, the disease is characterized by a lichenoid inflammatory infiltrate and vacuolar degeneration of the basal layer of the epidermis. Apr 28, 2023 · Is morphea caused by stress? Read further to get your answers! What is the link between Morphea and stress? According to a study, there is evidence that suggests that stress may play a role in developing morphea. We found the morphea transcriptome is dominated by IFN-γ Mar 8, 2022 · Herein, we described our single centre experience of four cases of generalized morphea following COVID‐19 vaccination seen in the last 8 months (Fig. Symptoms worsen in cold weather or when handling cold objects. Morphea is an autoimmune disorder (such as type I diabetes, lupus, vitiligo, or multiple Mar 13, 2020 · Both the active disease, with typical “lilac ring” around the plaques, and the residual hypo-/hyperpigmented lesions might cause substantial discomfort for the patient. Stress is the secondary cause for about 80% diseases in today’s busy lifestyle, so it is important to relax body and mind with relaxation techniques, with meditation, biofeedback, self-hypnosis and other techniques that support and promote inner peace. When a health care provider suspects morphea, a blood test is done to rule out scleroderma , a related and more serious disorder. But stress may really be the cause. Morphea itself has a spectrum of manifestations ranging from skin only to multiple organ involvement. Figure 1. Now at age 27, I have marks on my back, hips, side and some of my arms. The table compares all the cases based on several factors such as age, gender, COVID‐19 vaccine type, interval between vaccination and symptoms, and other variables. Sometimes the bones and muscles underneath the patches of skin become affected as well. Please note that GARD cannot enroll individuals in clinical studies. 1 While the pathogenesis of this condition is unknown, several factors are assumed to be involved in the development of the disease, including a genetic predisposition, immune dysregulation, and environmental factors. Typically, the skin changes appear on the belly, chest or back. Typically, the morphea skin changes appear on the Aug 10, 2023 · By Mayo Clinic Staff. Collagen is a normal part of skin and many organs. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Most As previously reported, antigenic cross-reactivity between vaccine spike proteins and human tissues could cause certain immune-mediated diseases, including generalized morphea. Once we’re living with scleroderma, or any autoimmune disease, stress can significantly affect the severity of the disease and trigger flares. Tretinoin and a mild corticosteroid. Morphea causes patches of skin to thicken into firm, oval-shaped areas. 1a–d ). Limited Scleroderma. The amygdala interprets the images and sounds. The lesions normally appear on the extensor side of the four limbs and trunk, and gradually affect the entire body surface, including the head and neck, causing joint Mar 30, 2023 · TABLE 1. Jul 13, 2023 · Calcinosis: Calcium deposits form on skin. Morphea is associated with cosmetic and functional sequelae, and internal organ There is no specific treatment for morphea caused by stress. Originally I had one purple area on my stomach, however, it soon started to spread. wp bw xz xy tq ox zl gn iu ky